In vitro maturation IVM is the technique of letting the contents of ovarian follicles and the oocytes inside mature in vitro. It can be offered to women with infertility problems, combined with IVF, offering women pregnancy without ovarian stimulation. Oogenesis takes place during fetal life, in which primordial germ cells undergo mitosis until a few weeks prior to birth, forming oogonia. These then begin meiosis to form the oocyte within the primordial follicle. Babies are born with million primordial follicles, and by puberty have around ,
Clinical Application of In Vitro Maturation of Oocytes
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Folliculogenesis is remarkably similar in cattle and humans. In this review, we consider the known differences and provide a possible explanation for the greater success of oocyte in vitro maturation in cattle. Two different parallel processes that are critical for oocyte competence acquisition are examined. The first occurs in the follicle and in turn influences the oocyte, the second occurs within the oocyte itself and involves the gradual cessation of the transcription machinery with additional changes observable in the chromatin structure. We expect this insight to contribute to the improvement of human fertility programs based on in vitro fertilization, and particularly to the development of controlled ovarian stimulation protocols that yield more high-quality oocytes and thereby improve the clinical performance of treatments for infertility. The physiology of folliculogenesis in cattle and humans differs from that in mice in several ways [ 1 , 2 ], the most obvious being the number of follicles ovulated per cycle, followed by the timing of the processes by which oocytes acquire all of the capabilities necessary to yield healthy offspring.
In vitro maturation
January 9th Reviewed: June 6th Published: June 28th In vitro maturation IVM is a technique used to induce immature oocytes collected in different periods of embryonic growth.
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